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watch intently (one)pentobarbital will reduce the level or effect of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbital will reduce the extent or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/keep an eye on. powerful CYP3A4 inducers could decrease suvorexant efficacy;